The Cherries came from behind to beat 10-man Sparta Prague 3-1 in the Czech Republic, making it four wins from four in their maiden European campaign.
Ebrima Singhateh gave the hosts a first-half lead after Lewis Cook had missed a penalty for Bournemouth.
However, Sparta were reduced to 10 men when Tobias Guddal received a second yellow card, handing the visitors an opportunity to fight back.
READ: Five landmark matches from Ronaldo’s Portugal career
Tyler Adams equalised in the 57th minute before Evanilson put Bournemouth ahead with nine minutes remaining.
Rayan added a third late on to complete another impressive European outing for Marco Rose’s side.
Elsewhere, Milan’s miserable campaign continued with a 2-0 defeat to Ferencvaros at San Siro.
Haiti international Lenny Joseph scored twice after the break to condemn the Italian giants to their third defeat in four Europa League matches.
Ferencvaros maintained their perfect record despite finishing with 10 men following Bamidele Yusuf’s dismissal.
Crystal Palace rescued a point against Hoffenheim at Selhurst Park, with Daichi Kamada scoring a stoppage-time equaliser to secure a 1-1 draw.
Watch: Ronaldo bids farewell to international football
The Eagles had fallen behind to Alexander Prass and saw Adam Wharton sent off before their late recovery.
Celtic claimed a dramatic 3-2 victory over Besiktas in Glasgow, with Jhon Durán scoring twice for the Scottish side, including the decisive goal in the closing stages.
Sunderland endured a disappointing evening at the Stadium of Light, going down 2-0 to Dinamo Zagreb.
Juventus also collected three points with a 2-1 victory away to AZ Alkmaar, while Marseille secured a valuable 1-0 win against Bayer Leverkusen.
Union Saint-Gilloise continued their unbeaten campaign with a 2-1 triumph at Celta Vigo, while Anderlecht defeated Salzburg 2-0.
With the league phase reaching its halfway point, Bournemouth and Ferencvaros remain among the leading contenders for automatic qualification to the last 16.
Photo: Justin Setterfield/Getty Images
